HCID 86622721, compound → HCID 67019929, compound

HRID 1673229Notes

Reaction equation

HRID 1673229 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[CH:25]([NH:26][CH2:27][CH2:28][NH:29]C(=O)OC(C)(C)C)[CH2:24][C:23]([CH3:38])([CH3:37])[O:22][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]3[CH:25]([NH:26][CH2:27][CH2:28][NH2:29])[CH2:24][C:23]([CH3:38])([CH3:37])[O:22][C:11]3=[N:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 86622721HCID 86622721, compound

Product 1

HCID 67019929HCID 67019929, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the product of Step A (42.9 mg, 0.07 mmol) in 2.5 mL of 20% TFA in CH2Cl2 was stirred at rt for 1 h. The reaction mixture was concentrated to give the product which was used without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customto give the product which
  3. customwas used without further purification

Sources & evidence

ORD record
ord-5589d982b00c457c860d11a5f4720c1c
Source dataset
uspto-grants-2011_08
Patent number
US07999107B2

Reaction notes

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