Citric Acid → HCID 57879555, compound

Participants

Reaction Conditions

Reaction Steps

0.037 mL of vinylcyclohexane, 87 mg of cesium carbonate, 13 mg of tetrabutylammonium bromide and 21 mg of polymer supported di(acetato)dicyclohexylphosphino palladium(11) were added to 1.0 mL of toluene solution containing 50 mg of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature and stirred at 110° C. for 48 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added. The organic layer was separated, and the solvent was evaporated under reduced pressure after washed with 10% citric acid aqueous solution. 5 mL of trifluoroacetic acid; was added to the obtained residue and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 55-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 2.9 mg of 2-(benzamido)-4-((E)-2-cyclohexylvinyl)benzoic acid as white solid.

Provenance & Evidence