Citric Acid → HCID 57879555, compound

HRID 1673378Notes

Reaction equation

HRID 1673378 reaction equation
[CH:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)=[CH2:2].C(=O)([O-])[O-].[Cs+].[Cs+].[C:15]([NH:23][C:24]1[CH:36]=[C:35](Br)[CH:34]=[CH:33][C:25]=1[C:26]([O:28]C(C)(C)C)=[O:27])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C(OCC)(=O)C.C1(C)C=CC=CC=1>[C:15]([NH:23][C:24]1[CH:36]=[C:35](/[CH:2]=[CH:1]/[CH:3]2[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]2)[CH:34]=[CH:33][C:25]=1[C:26]([OH:28])=[O:27])(=[O:22])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

8

Reactant 4

HCID 311Citric AcidHCID 10796Cesium carbonateHCID 12757VinylcyclohexaneHCID 67343005Tert-butyl 2-(benzamido)-4-bromobenzoate

Product 1

HCID 57879555HCID 57879555, compound

Reagents, catalysts & solvents 3

HCID 74236Tetrabutylammonium BromideCatalystHCID 1140TolueneSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
110 °C

Procedure

0.037 mL of vinylcyclohexane, 87 mg of cesium carbonate, 13 mg of tetrabutylammonium bromide and 21 mg of polymer supported di(acetato)dicyclohexylphosphino palladium(11) were added to 1.0 mL of toluene solution containing 50 mg of tert-butyl 2-(benzamido)-4-bromobenzoate at room temperature and stirred at 110° C. for 48 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 10% citric acid aqueous solution were added. The organic layer was separated, and the solvent was evaporated under reduced pressure after washed with 10% citric acid aqueous solution. 5 mL of trifluoroacetic acid; was added to the obtained residue and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 55-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 2.9 mg of 2-(benzamido)-4-((E)-2-cyclohexylvinyl)benzoic acid as white solid.

Workup

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. customThe organic layer was separated
  3. customthe solvent was evaporated under reduced pressure
  4. washafter washed with 10% citric acid aqueous solution
  5. additionwas added to the obtained residue
  6. stirringstirred at room temperature for 1 hour
  7. customThe solvent was evaporated under reduced pressure
  8. customthe obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 55-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution]

Sources & evidence

ORD record
ord-664cee59ba464bdea5cab9255267215b
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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