Trifluoroacetic acid → HCID 57879541, compound

HRID 1673393Notes

Reaction equation

FC(F)(F)C(O)=O.[Br:8][C:9]1[CH:10]=[C:11]([CH:35]=[CH:36][CH:37]=1)[C:12]([NH:14][C:15]1[CH:27]=[C:26]([O:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:16]=1[C:17]([O:19]C(C)(C)C)=[O:18])=[O:13]>>[Br:8][C:9]1[CH:10]=[C:11]([CH:35]=[CH:36][CH:37]=1)[C:12]([NH:14][C:15]1[CH:27]=[C:26]([O:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:25]=[CH:24][C:16]=1[C:17]([OH:19])=[O:18])=[O:13]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67344602HCID 67344602, compound

Product 1

HCID 57879541HCID 57879541, compound

Procedure

5 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(3-bromobenzamido)-4-phenoxybenzoate and stirred at room temperature for 5 minutes. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 31 mg of 2-(3-bromobenzamido)-4-phenoxybenzoic acid as white solid.

Workup

customThe solvent was evaporated under reduced pressure and diisopropyl ether
additionwas added to the obtained residue
customa solid substance was separated by filtration

Sources & evidence

ORD record: ord-b04a8010a00c4f76b7eac55a3700d877
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07999132B2

Reaction notes

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