Trifluoroacetic acid → HCID 57879398, compound

HRID 1673397Notes

Reaction equation

FC(F)(F)C(O)=O.[O:8]([C:15]1[CH:27]=[CH:26][C:18]([C:19]([O:21]C(C)(C)C)=[O:20])=[C:17]([NH:28][C:29](=[O:38])[CH2:30][O:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[O:8]([C:15]1[CH:27]=[CH:26][C:18]([C:19]([OH:21])=[O:20])=[C:17]([NH:28][C:29](=[O:38])[CH2:30][O:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:16]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67343309HCID 67343309, compound

Product 1

HCID 57879398HCID 57879398, compound

Procedure

3 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-phenoxy-2-(2-phenoxyacetamido)benzoate and stirred at room temperature for 1 hour. The solvent was evaporated 3 under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 38 mg of 4-phenoxy-2-(2-phenoxyacetamido)benzoic acid as white solid.

Workup

customThe solvent was evaporated 3 under reduced pressure and diisopropyl ether
additionwas added to the obtained residue
customa solid substance was separated by filtration

Sources & evidence

ORD record: ord-0fc667cc421445f7a2bf676ae827094b
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07999132B2

Reaction notes

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