反应详情

0.090 mL of 2.0 mol/L aqueous sodium hydroxide was added dropwise to a mixed solution of 1 mL of methanol and 1 mL of tetrahydrofuran containing 45 mg of methyl 2-(benzamido)-4-(3-phenylpropoxy)benzoate while ice-cooled and stirred at room temperature for 14 hours and 30 minutes. 0.15 mL of 2.0 mol/L aqueous sodium hydroxide was added dropwise and stirred at the same temperature for 5 hours and 30 minutes. The solvent was evaporated under reduced pressure and water was added and pH was adjusted to pH 4.0 with 1.0 mol/L hydrochloric acid. A solid substance was separated by filtration to obtain 32 mg of 2-(benzamido)-4-(3-phenylpropoxy)benzoic acid as white solid.

1. temperaturecooled
2. stirringstirred at the same temperature for 5 hours and 30 minutes
3. customThe solvent was evaporated under reduced pressure and water
4. additionwas added
5. customA solid substance was separated by filtration