反应详情

温度

40 °C

0.077 mL of 2.0 mol/L aqueous sodium hydroxide was added drop-wise to a mixed solution of 1 mL of methanol and 1 mL of tetrahydrofuran containing 35 mg of methyl 2-(benzamido)-4-(cyclohexyloxy)benzoate at room temperature and stirred at the same temperature overnight and at 40° C. for 6 hours and 30 minutes. 0.050 mL of 2.0 mol/L aqueous sodium hydroxide was added at room temperature and stirred at she same temperature for 4 hours and 30 minutes. The solvent was evaporated under reduced pressure and water was added and pH was adjusted to pH 4.0 with 1.0 mol/L hydrochloric acid. A solid substance was separated by filtration to obtain 25 mg of 2-(benzamido)-4-(cyclohexyloxy)benzoic acid as white solid.

1. stirringstirred at she same temperature for 4 hours and 30 minutes
2. customThe solvent was evaporated under reduced pressure and water
3. additionwas added
4. customA solid substance was separated by filtration