反应详情

0.50 mL of 2.0 mol/L aqueous sodium hydroxide was added dropwise to a mixed solution of 3 mL of methanol and 3 mL of tetrahydrofuran containing 0.29 g of methyl 2-(benzamido)-4-((phenylthio)methyl)benzoate while ice-cooled and stirred at room temperature for 5 hours. 0.25 mL of 2.0 mol/L aqueous sodium hydroxide was added dropwise and stirred at the same temperature for 14 hours. The solvent was evaporated under reduced pressure and water was added and pH was adjusted to pH 4.0 with 1.0 mol/L hydrochloric acid. A solid substance was separated by filtration to obtain 0.28 g of 2-(benzamido)-4-((phenylthio)methyl)benzoic acid as white solid.

1. temperaturecooled
2. stirringstirred at the same temperature for 14 hours
3. customThe solvent was evaporated under reduced pressure and water
4. additionwas added
5. customA solid substance was separated by filtration