HCID 67342396, compound → HCID 57879501, compound

HRID 1673436Notes

Reaction equation

HRID 1673436 reaction equation
C(OC([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:27]=[CH:26][C:18]([C:19]([O:21]C(C)(C)C)=[O:20])=[C:17]([NH:28][C:29](=[O:37])[C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)[CH:16]=2)=[CH:11][CH:10]=1)=O)(C)(C)C>FC(F)(F)C(O)=O>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:27]=[CH:26][C:18]([C:19]([OH:21])=[O:20])=[C:17]([NH:28][C:29](=[O:37])[C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)[CH:16]=2)=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 67342396HCID 67342396, compound

Product 1

HCID 57879501HCID 57879501, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-(4-(tert-butoxycarbonyl)oxyphenyl)-2-(4-fluorobenzamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 49 mg of 4-(4-hydroxyphenyl)-2-(4-fluorobenzamido)benzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-8a9bcd92025b483482f5178b01ac9d0c
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

Loading…