HCID 67344496, compound → HCID 57879575, compound

HRID 1673440Notes

Reaction equation

HRID 1673440 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:22]=[CH:21][C:13]([C:14]([O:16]C(C)(C)C)=[O:15])=[C:12]([NH:23][C:24](=[O:33])[C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=2[CH3:32])[CH:11]=1>FC(F)(F)C(O)=O>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[C:10]1[CH:22]=[CH:21][C:13]([C:14]([OH:16])=[O:15])=[C:12]([NH:23][C:24](=[O:33])[C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=2[CH3:32])[CH:11]=1

Participants

3

Reactant 1

HCID 67344496HCID 67344496, compound

Product 1

HCID 57879575HCID 57879575, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-(benzofuran-2-yl)-2-(2,3-dimethylbenzamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and ethyl acetate was added to the obtained residue and a solid substance was separated by filtration to obtain 15 mg of 4-(benzofuran-2-yl)-2-(2,3-dimethylbenzamido)benzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and ethyl acetate
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-850130296f7d49e5ad397ac6341124de
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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