HCID 67344207, compound → HCID 57879588, compound

HRID 1673448Notes

Reaction equation

HRID 1673448 reaction equation
[CH3:1][C:2]1[C:33]([CH3:34])=[CH:32][CH:31]=[CH:30][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18](/[CH:20]=[CH:21]/[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=2)[CH:17]=[CH:16][C:8]=1[C:9]([O:11]C(C)(C)C)=[O:10])=[O:5]>FC(F)(F)C(O)=O>[CH3:1][C:2]1[C:33]([CH3:34])=[CH:32][CH:31]=[CH:30][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18](/[CH:20]=[CH:21]/[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=2)[CH:17]=[CH:16][C:8]=1[C:9]([OH:11])=[O:10])=[O:5]

Participants

3

Reactant 1

HCID 67344207HCID 67344207, compound

Product 1

HCID 57879588HCID 57879588, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2,3-dimethylbenzamido)-4-((E)-2-(3-methoxyphenyl)vinyl)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 15 mg of 2-(2,3-dimethylbenzamido)-4-((E)-2-(3-methoxyphenyl)vinyl)benzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and methanol
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-08d740c30fe44815998151e88c16e7fa
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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