反应详情

5.0 mg of 5% palladium-carbon was added to a mixed solution of 1.0 mL of methanol and 0.5 mL of ethyl acetate containing 25 mg of 2-(benzamido)-4-(2-cyclopenten-1-yl)benzoic acid and stirred at room temperature under hydrogen atmosphere for 7 hours and then at 40° C. for 8 hours and stirred at 45° C. for 15 hours. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. Methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 16 mg of 2-(benzamido)-4-cyclopentyl benzoic acid as white solid.

1. waitat 40° C. for 8 hours
2. stirringstirred at 45° C. for 15 hours
3. customInsoluble were removed by filtration
4. customthe solvent was evaporated under reduced pressure
5. additionMethanol was added to the obtained residue
6. customa solid substance was separated by filtration