反应详情

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(3-(hydroxymethyl)phenyl)benzoate and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 60-100% acetonitrile 0.1% trifluoroacetic acid aqueous solution] to obtain 12 mg of 2-(benzamido)-4-(3-(hydroxymethyl)phenyl)benzoic acid as white solid.

1. customThe solvent was evaporated under reduced pressure
2. customthe obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 60-100% acetonitrile 0.1% trifluoroacetic acid aqueous solution]