Tert-butyl 2-(benzamido)-4-(2-chloro-6-fluorophenyl)benzoate → 2-(Benzamido)-4-(2-chloro-6-fluorophenyl)benzoic acid

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Reaction Steps

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(2-chloro-6-fluorophenyl)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and toluene was added. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 70-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 5.8 mg of 2-(benzamido)-4-(2-chloro-6-fluorophenyl)benzoic acid as white solid.

Provenance & Evidence