反应详情

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(2-chloro-6-fluorophenyl)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and toluene was added. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 70-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 5.8 mg of 2-(benzamido)-4-(2-chloro-6-fluorophenyl)benzoic acid as white solid.

1. customThe solvent was evaporated under reduced pressure and toluene
2. additionwas added
3. customThe solvent was evaporated under reduced pressure
4. customthe obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 70-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution]