反应详情

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(3-chloro-4-hydroxyphenyl)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and toluene was added. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 94 mg of 2-(benzamido)-4-(3-chloro-4-hydroxyphenyl)benzoic acid as white solid.

1. customThe solvent was evaporated under reduced pressure and toluene
2. additionwas added
3. customThe solvent was evaporated under reduced pressure and diisopropyl ether
4. additionwas added to the obtained residue
5. customa solid substance was separated by filtration