HCID 67343100, compound → HCID 57879609, compound

HRID 1673475Notes

Reaction equation

HRID 1673475 reaction equation
[C:1]([NH:9][C:10]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([Cl:30])[CH:24]=2)[CH:20]=[CH:19][C:11]=1[C:12]([O:14]C(C)(C)C)=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[C:1]([NH:9][C:10]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[C:25]([Cl:30])[CH:24]=2)[CH:20]=[CH:19][C:11]=1[C:12]([OH:14])=[O:13])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 67343100HCID 67343100, compound

Product 1

HCID 57879609HCID 57879609, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(3-chloro-4-hydroxyphenyl)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and toluene was added. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 94 mg of 2-(benzamido)-4-(3-chloro-4-hydroxyphenyl)benzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and toluene
  2. additionwas added
  3. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  4. additionwas added to the obtained residue
  5. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-b926cd7a6f174abca2b929866630bce7
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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