Methanol → HCID 57879428, compound

HRID 1673478Notes

Reaction equation

HRID 1673478 reaction equation
CO.[N+:3]([C:6]1[CH:31]=[CH:30][C:9]([C:10]([NH:12][C:13]2[CH:21]=[C:20]([CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:19]=[CH:18][C:14]=2[C:15]([OH:17])=[O:16])=[O:11])=[CH:8][CH:7]=1)([O-])=O>[C].[Pd].C(OCC)(=O)C>[NH2:3][C:6]1[CH:7]=[CH:8][C:9]([C:10]([NH:12][C:13]2[CH:21]=[C:20]([CH2:22][CH2:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:19]=[CH:18][C:14]=2[C:15]([OH:17])=[O:16])=[O:11])=[CH:30][CH:31]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 57879325HCID 57879325, compound

Product 1

HCID 57879428HCID 57879428, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8857Ethyl AcetateSolvent

Procedure

2.0 mg of 5% palladium-carbon was added to a mixed solution of 1.0 mL of methanol and 2.0 mL of ethyl acetate containing 7.0 mg of 2-(4-nitrobenzamido)-4-phenethylbenzoic acid and stirred under hydrogen atmosphere at room temperature for 2 hours. After insoluble were removed by filtration, the solvent was evaporated under reduced pressure to obtain 4.0 mg of 2-(4-aminobenzamido)-4-phenethylbenzoic acid as pale yellow solid.

Workup

  1. customAfter insoluble were removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-43fe79deadc64db4add286313f49cc1d
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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