Trifluoroacetic acid → HCID 57879358, compound

HRID 1673480Notes

Reaction equation

HRID 1673480 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:38]=[CH:37][CH:36]=[C:35]([Cl:39])[C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([CH2:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>>[Cl:8][C:9]1[CH:38]=[CH:37][CH:36]=[C:35]([Cl:39])[C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([CH2:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67344250HCID 67344250, compound

Product 1

HCID 57879358HCID 57879358, compound

Procedure

3.0 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2,6-dichlorobenzamido)-4-phenethylbenzoate and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 18 mg of 2-(2,6-dichlorobenzamido)-4-phenethylbenzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-b97fc8f3345a4d89a6ca9273116ea46a
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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