Trifluoroacetic acid → HCID 57879439, compound

HRID 1673482Notes

Reaction equation

HRID 1673482 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>>[Cl:8][C:9]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67345261HCID 67345261, compound

Product 1

HCID 57879439HCID 57879439, compound

Procedure

3.0 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2,6-dichlorobenzamido)-4-phenylbenzoate and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure and diisopropyl ether was added no the obtained residue and a solid substance was separated by filtration to obtain 0.10 g of 2-(2,6-dichlorobenzamido)-4-phenylbenzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added no the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-33dd7035d5534a399151d3edaeb8a6b0
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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