Trifluoroacetic acid → HCID 57879464, compound

HRID 1673484Notes

Reaction equation

HRID 1673484 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>>[Cl:8][C:9]1[CH:37]=[CH:36][CH:35]=[C:34]([Cl:38])[C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67342146HCID 67342146, compound

Product 1

HCID 57879464HCID 57879464, compound

Procedure

3.0 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2,6-dichlorobenzamido)-4-phenoxybenzoate and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 70 mg of 2-(2,6-dichlorobenzamido)-4-phenoxybenzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-7152b13b0f734259afa33bfc890b53db
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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