反应详情

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-phenoxy-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and water was added and pH was adjusted to pH 6.5 with a saturated sodium hydrogen carbonate aqueous solution. A solid substance was separated by filtration to obtain 23 mg of 4-phenoxy-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoic acid as whine solid.

1. customThe solvent was evaporated under reduced pressure and water
2. additionwas added
3. customA solid substance was separated by filtration