HCID 67344528, compound → HCID 57879521, compound

HRID 1673489Notes

Reaction equation

HRID 1673489 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:17]=[CH:16][C:8]=1[C:9]([O:11]C(C)(C)C)=[O:10])=[O:5]>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[C:4]([NH:6][C:7]1[CH:19]=[C:18]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:17]=[CH:16][C:8]=1[C:9]([OH:11])=[O:10])=[O:5]

Participants

3

Reactant 1

HCID 67344528HCID 67344528, compound

Product 1

HCID 57879521HCID 57879521, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2-fluorobenzamido)-4-phenoxybenzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 30 mg of 2-(2-fluorobenzamido)-4-phenoxybenzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-d4b2ea4bd2a44d74ae2ad4ed7ff8853e
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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