反应详情

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-phenyl-2-(5-(1H-pyrrol-1-yl)pyridine-3-carboxamido)benzoate and stirred an room temperature for 2 hours. The solvent was evaporated under reduced pressure, ethyl acetate and water were added and pH was adjusted to pH 7.0 with a saturated sodium hydrogen carbonate aqueous solution. The organic layer was separated and the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 23 mg of 4-phenyl-2-(5-(1H-pyrrol-1-yl)pyridine-3-carboxamido)benzoic acid as white solid.

1. customThe solvent was evaporated under reduced pressure, ethyl acetate and water
2. additionwere added
3. customThe organic layer was separated
4. customthe solvent was evaporated under reduced pressure
5. additionDiisopropyl ether was added to the obtained residue
6. customa solid substance was separated by filtration