tert-butyl 2-((E)-3-(4-acetoxyphenyl)acrylamido)-4-phenoxybenzoate → 2-((E)-3-(4-acetoxyphenyl)acrylamido)-4-phenoxybenzoic acid

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Reaction Steps

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-((E)-3-(4-acetoxyphenyl)acrylamido)-4-phenoxybenzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 60-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 34 mg of 2-((E)-3-(4-acetoxyphenyl)acrylamido)-4-phenoxybenzoic acid as white solid.

Provenance & Evidence