反应详情

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-((E)-3-(4-acetoxyphenyl)acrylamido)-4-phenoxybenzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 60-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 34 mg of 2-((E)-3-(4-acetoxyphenyl)acrylamido)-4-phenoxybenzoic acid as white solid.

1. customThe solvent was evaporated under reduced pressure
2. customthe obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 60-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution]