Trifluoroacetic acid → HCID 57879432, compound

HRID 1673516Notes

Reaction equation

FC(F)(F)C(O)=O.[C:8]([NH:16][C:17]1[CH:29]=[C:28]([N:30]2[C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=3[N:32]=[CH:31]2)[CH:27]=[CH:26][C:18]=1[C:19]([O:21]C(C)(C)C)=[O:20])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:8]([NH:16][C:17]1[CH:29]=[C:28]([N:30]2[C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=3[N:32]=[CH:31]2)[CH:27]=[CH:26][C:18]=1[C:19]([OH:21])=[O:20])(=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67344136HCID 67344136, compound

Product 1

HCID 57879432HCID 57879432, compoundYield 81.7%

Procedure

5.0 mL trifluoroacetic acid solution containing 34 mg of tert-butyl 2-(benzamido)-4-(1H-benzimidazol-1-yl)benzoate was stirred at room temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure and methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 24 mg of 2-(benzamido)-4-(1H-benzimidazol-1-yl)benzoic acid as white solid.

Workup

customThe solvent was evaporated under reduced pressure and methanol
additionwas added to the obtained residue
customa solid substance was separated by filtration

Sources & evidence

ORD record: ord-7cdcac72d32845db92f314dc2dd2a3d4
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07999132B2

Reaction notes

Loading…