Trifluoroacetic acid → HCID 57879592, compound

HRID 1673519Notes

Reaction equation

FC(F)(F)C(O)=O.[C:8]([NH:16][C:17]1[CH:29]=[C:28]([C:30]2[CH:35]=[CH:34][C:33]([CH3:36])=[C:32]([Cl:37])[CH:31]=2)[CH:27]=[CH:26][C:18]=1[C:19]([O:21]C(C)(C)C)=[O:20])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:8]([NH:16][C:17]1[CH:29]=[C:28]([C:30]2[CH:35]=[CH:34][C:33]([CH3:36])=[C:32]([Cl:37])[CH:31]=2)[CH:27]=[CH:26][C:18]=1[C:19]([OH:21])=[O:20])(=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67341350HCID 67341350, compound

Product 1

HCID 57879592HCID 57879592, compound

Procedure

5.0 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(3-chloro-4-Methylphenyl)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 14 mg of 2-(benzamido)-4-(3-chloro-4-methylphenyl)benzoic acid as white solid.

Workup

customThe solvent was evaporated under reduced pressure and methanol
additionwas added to the obtained residue
customa solid substance was separated by filtration

Sources & evidence

ORD record: ord-446db38140e04e7782ce58f80a18bd6f
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07999132B2

Reaction notes

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