Tert-butyl 2-(3,5-dichlorobenzamido)-4-phenethylbenzoate → 2-(3,5-Dichlorobenzamido)-4-phenethylbenzoic acid

HRID 1673521Notes

Reaction equation

HRID 1673521 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([Cl:32])[CH:31]=1)[C:5]([NH:7][C:8]1[CH:20]=[C:19]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]=[CH:17][C:9]=1[C:10]([O:12]C(C)(C)C)=[O:11])=[O:6]>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([Cl:32])[CH:31]=1)[C:5]([NH:7][C:8]1[CH:20]=[C:19]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]=[CH:17][C:9]=1[C:10]([OH:12])=[O:11])=[O:6]

Participants

3

Reactant 1

HCID 67342900Tert-butyl 2-(3,5-dichlorobenzamido)-4-phenethylbenzoate

Product 1

HCID 578793712-(3,5-Dichlorobenzamido)-4-phenethylbenzoic acid

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(3,5-dichlorobenzamido)-4-phenethylbenzoate and stirred ad room temperature for 2 hours. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 62 mg of 2-(3,5-dichlorobenzamido)-4-phenethylbenzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-5d20bbaa6fc0414cb1d4f043dab69282
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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