HCID 67345378, compound → 4-phenethyl-2-(3-phenyl-1H-pyrazole-5-carboxamido)benzoic acid

HRID 1673528Notes

Reaction equation

HRID 1673528 reaction equation
[CH2:1]([C:9]1[CH:21]=[CH:20][C:12]([C:13]([O:15]C(C)(C)C)=[O:14])=[C:11]([NH:22][C:23]([C:25]2[NH:29][N:28]=[C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:26]=2)=[O:24])[CH:10]=1)[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>FC(F)(F)C(O)=O>[CH2:1]([C:9]1[CH:21]=[CH:20][C:12]([C:13]([OH:15])=[O:14])=[C:11]([NH:22][C:23]([C:25]2[NH:29][N:28]=[C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:26]=2)=[O:24])[CH:10]=1)[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 67345378HCID 67345378, compound

Product 1

HCID 578795624-phenethyl-2-(3-phenyl-1H-pyrazole-5-carboxamido)benzoic acid

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-phenethyl-2-(3-phenyl-1H-pyrazole-5-carboxamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure, and the obtained residue was purified with silica gel column chromatography [Flash Tube 2008 manufactured by Trikonex Company, eluent; ethyl acetate] to obtain 2.6 mg of 4-phenethyl-2-(3-phenyl-1H-pyrazole-5-carboxamido)benzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe obtained residue was purified with silica gel column chromatography [Flash Tube 2008 manufactured by Trikonex Company, eluent; ethyl acetate]

Sources & evidence

ORD record
ord-cd761553d4d54cb3959e2265c3180f21
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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