反应详情

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-phenethyl-2-(3-phenyl-1H-pyrazole-5-carboxamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure, and the obtained residue was purified with silica gel column chromatography [Flash Tube 2008 manufactured by Trikonex Company, eluent; ethyl acetate] to obtain 2.6 mg of 4-phenethyl-2-(3-phenyl-1H-pyrazole-5-carboxamido)benzoic acid as white solid.

1. customThe solvent was evaporated under reduced pressure
2. customthe obtained residue was purified with silica gel column chromatography [Flash Tube 2008 manufactured by Trikonex Company, eluent; ethyl acetate]