Trifluoroacetic acid → HCID 57879405, compound

HRID 1673543Notes

Reaction equation

HRID 1673543 reaction equation
FC(F)(F)C(O)=O.[C:8]([C:10]1[CH:11]=[C:12]([CH:35]=[CH:36][CH:37]=1)[C:13]([NH:15][C:16]1[CH:28]=[C:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:26]=[CH:25][C:17]=1[C:18]([O:20]C(C)(C)C)=[O:19])=[O:14])#[N:9]>C(Cl)Cl>[C:8]([C:10]1[CH:11]=[C:12]([CH:35]=[CH:36][CH:37]=1)[C:13]([NH:15][C:16]1[CH:28]=[C:27]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:26]=[CH:25][C:17]=1[C:18]([OH:20])=[O:19])=[O:14])#[N:9]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67342805HCID 67342805, compound

Product 1

HCID 57879405HCID 57879405, compoundYield 88.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.5 mL of trifluoroacetic acid was added to 0.5 mL of methylene chloride solution containing 10 mg of tert-butyl 2-(3-cyanobenzamido)-4-phenylbenzoate and stirred at room temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 7.6 mg of 2-(3-cyanobenzamido)-4-phenylbenzoic acid as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure and diisopropyl ether
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Sources & evidence

ORD record
ord-1ad51b384d2e449ca5e664101aa40a76
Source dataset
uspto-grants-2011_08
Patent number
US07999132B2

Reaction notes

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