Trifluoroacetic acid → HCID 57879333, compound

HRID 1673553Notes

Reaction equation

FC(F)(F)C(O)=O.[C:8]([NH:16][C:17]1[CH:29]=[C:28]([O:30][C:31]2[CH:36]=[C:35]([F:37])[CH:34]=[C:33]([F:38])[CH:32]=2)[CH:27]=[CH:26][C:18]=1[C:19]([O:21]C(C)(C)C)=[O:20])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:8]([NH:16][C:17]1[CH:29]=[C:28]([O:30][C:31]2[CH:32]=[C:33]([F:38])[CH:34]=[C:35]([F:37])[CH:36]=2)[CH:27]=[CH:26][C:18]=1[C:19]([OH:21])=[O:20])(=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67345242HCID 67345242, compound

Product 1

HCID 57879333HCID 57879333, compoundYield 68.4%

Procedure

5.0 mL of trifluoroacetic acid solution containing 69 mg of tert-butyl 2-(benzamido)-4-(3,5-difluorophenoxy)benzoate was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 41 mg of 2-(benzamido)-4-(3,5-difluorophenoxy)benzoic acid as white solid.

Workup

customThe solvent was evaporated under reduced pressure and diisopropyl ether
additionwas added to the obtained residue
customa solid substance was separated by filtration

Sources & evidence

ORD record: ord-fad6e892a7014f3cb1ade58e5ba38b5b
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07999132B2

Reaction notes

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