Trifluoroacetic acid → HCID 57879542, compound

HRID 1673562Notes

Reaction equation

FC(F)(F)C(O)=O.[C:8]([NH:16][C:17]1[CH:29]=[C:28]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([N+:37]([O-:39])=[O:38])[CH:32]=2)[CH:27]=[CH:26][C:18]=1[C:19]([O:21]C(C)(C)C)=[O:20])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:8]([NH:16][C:17]1[CH:29]=[C:28]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([N+:37]([O-:39])=[O:38])[CH:32]=2)[CH:27]=[CH:26][C:18]=1[C:19]([OH:21])=[O:20])(=[O:15])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67343890HCID 67343890, compound

Product 1

HCID 57879542HCID 57879542, compound

Procedure

5.0 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(3-nitrophenoxy)benzoate and stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure and diisopropyl ether was added to the obtained residue and a solid substance was separated by filtration to obtain 34 mg of 2-(benzamido)-4-(3-nitrophenoxy)benzoic acid as pale yellow solid.

Workup

customThe solvent was evaporated under reduced pressure and diisopropyl ether
additionwas added to the obtained residue
customa solid substance was separated by filtration

Sources & evidence

ORD record: ord-ce238d4145634caa859edd7cf7a3c4ec
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07999132B2

Reaction notes

Loading…