反应详情

5.0 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(2,4-dichlorophenoxy)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 80-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 8.7 mg of 2-(benzamido)-4-(2,4-dichlorophenoxy)benzoic acid as white solid.

1. customThe solvent was evaporated under reduced pressure
2. customthe obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 80-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution]