Potassium Carbonate → HCID 57460065, compound

HRID 1673588Notes

Reaction equation

[CH2:1]([C:3]1[N:8]=[C:7]([CH2:9][CH2:10][CH3:11])[NH:6][C:5](=[O:12])[CH:4]=1)[CH3:2].Br[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[C:22]([C:27]#[N:28])=[CH:23][CH:24]=[CH:25][CH:26]=2)=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:1]([C:3]1[N:8]=[C:7]([CH2:9][CH2:10][CH3:11])[N:6]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([C:21]3[C:22]([C:27]#[N:28])=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:19][CH:20]=2)[C:5](=[O:12])[CH:4]=1)[CH3:2]

Participants

Conditions

Temperature: 50 °C

Procedure

To a solution of 6-ethyl-2-propylpyrimidin-4(3H)-one (5.0 g) and 4′-(bromomethyl)biphenyl-2-carbonitrile (9.0 g) in acetonitrile (150 mL) was added potassium carbonate (8.32 g), and the mixture was stirred at 50° C. for 12 hr. The insoluble material was filtered off, the filtrate was concentrated, and the residue was purified by silica gel column chromatography to give the title compound (4.95 g, 46%) as a colorless viscous substance.

Workup

filtrationThe insoluble material was filtered off
concentrationthe filtrate was concentrated
customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record: ord-34f0719ca5af4d1c8c368d40895673e4
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07998968B2

Reaction notes

Loading…