Methyl iodide → HCID 136026828, compound

HRID 1673704Notes

Reaction equation

HRID 1673704 reaction equation
[CH2:1]([C:5]1[N:6]=[C:7]([SH:27])[NH:8][C:9](=[O:26])[C:10]=1[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:19]([C:24]#[N:25])=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:14][CH:13]=1)[CH2:2][CH2:3][CH3:4].I[CH3:29].[OH-].[K+]>CO>[CH2:1]([C:5]1[N:6]=[C:7]([S:27][CH3:29])[NH:8][C:9](=[O:26])[C:10]=1[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:19]([C:24]#[N:25])=[CH:20][CH:21]=[CH:22][CH:23]=2)=[CH:14][CH:13]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 178441883HCID 178441883, compound

Product 1

HCID 136026828HCID 136026828, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4′-[(4-butyl-2-mercapto-6-oxo-1,6-dihydropyrimidin-5-yl)methyl]biphenyl-2-carbonitrile (2.3 g), iodomethane (0.54 mL), potassium hydroxide (0.44 g) and methanol (20 mL) was stirred at room temperature for 3 hr. The obtained crystallized product was collected by filtration and washed with water and diethyl ether to give the title compound as colorless crystals (1.98 g, 83%).

Workup

  1. customThe obtained crystallized product
  2. filtrationwas collected by filtration
  3. washwashed with water and diethyl ether

Sources & evidence

ORD record
ord-525685468f064b3ca0cd45eb2e566ab5
Source dataset
uspto-grants-2011_08
Patent number
US07998968B2

Reaction notes

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