Bicarbonate Ion → 2-Chloro-1-(5-pyrimidin-2-yl-3',6'-dihydro-2'H-[2,4']bipyridinyl-1'-yl)-ethanone

HRID 167396Notes

Reaction equation

HRID 167396 reaction equation
[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[Cl:1][CH2:2][C:3](=[O:4])[Cl:5].[Na+:35].[O-:31][C:32]([OH:33])=[O:34].[n:6]1[c:7](-[c:12]2[cH:13][cH:14][c:15]([C:18]3=[CH:23][CH2:22][NH:21][CH2:20][CH2:19]3)[n:16][cH:17]2)[n:8][cH:9][cH:10][cH:11]1>>[Cl:1][CH2:2][C:3](=[O:4])[N:21]1[CH2:20][CH2:19][C:18]([c:15]2[cH:14][cH:13][c:12](-[c:7]3[n:6][cH:11][cH:10][cH:9][n:8]3)[cH:17][n:16]2)=[CH:23][CH2:22]1

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 589464495-Pyrimidin-2-yl-1',2',3',6'-tetrahydro-[2,4']bipyridinyl

Product 1

HCID 589464642-Chloro-1-(5-pyrimidin-2-yl-3',6'-dihydro-2'H-[2,4']bipyridinyl-1'-yl)-ethanone

Sources & evidence

ORD record
ord-ce6a74219ae24a37af9c6ae1bc09db9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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