HRID1674161

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21866389

未命名化合物

结构：CCCCc1nc(C)n(Cc2cc(C)n(C)n2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1

HCID136026844

未命名化合物

PRODUCTS

生成物

结构：CCCCc1nc(C)n(Cc2cc(C)n(C)n2)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1.Cl

HCID136331125

未命名化合物

收率 68%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a mixture of 6-butyl-3-[(1,5-dimethyl-1H-pyrazol-3-yl)methyl]-2-methyl-5-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}pyrimidin-4(3H)-one (0.25 g) and ethyl acetate (10 mL) was added 4 M hydrochloric acid-ethyl acetate (0.14 mL) at room temperature. The obtained crystallized product was collected by filtration to give the title compound as colorless crystals (0.18 g, 68%).

WORKUP

后处理

customThe obtained crystallized product
filtrationwas collected by filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-71898d58cbae403f87773bee0c0fca26
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07998968B2
来源说明: uspto-grants-2011_08

反应 SMILES

[CH2:1]([C:5]1[N:10]=[C:9]([CH3:11])[N:8]([CH2:12][C:13]2[CH:17]=[C:16]([CH3:18])[N:15]([CH3:19])[N:14]=2)[C:7](=[O:20])[C:6]=1[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[C:34]2[NH:38][C:37](=[O:39])[O:36][N:35]=2)=[CH:24][CH:23]=1)[CH2:2][CH2:3][CH3:4].[ClH:40].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:40].[CH2:1]([C:5]1[N:10]=[C:9]([CH3:11])[N:8]([CH2:12][C:13]2[CH:17]=[C:16]([CH3:18])[N:15]([CH3:19])[N:14]=2)[C:7](=[O:20])[C:6]=1[CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[C:34]2[NH:38][C:37](=[O:39])[O:36][N:35]=2)=[CH:24][CH:23]=1)[CH2:2][CH2:3][CH3:4]