HRID1674163

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21866389

未命名化合物

结构：CCCc1nc(C)n(Cc2nn(C)c3ccccc23)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1

HCID136026861

未命名化合物

PRODUCTS

生成物

结构：CCCc1nc(C)n(Cc2nn(C)c3ccccc23)c(=O)c1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1.Cl

HCID136203357

未命名化合物

收率 83%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

To a mixture of 2-methyl-3-[(1-methyl-1H-indazol-3-yl)methyl]-5-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one (0.38 g) and ethyl acetate (10 mL) was added 4 M hydrochloric acid-ethyl acetate (0.19 mL) at room temperature. The obtained crystallized product was collected by filtration to give the title compound as colorless crystals (0.33 g, 83%).

WORKUP

后处理

customThe obtained crystallized product
filtrationwas collected by filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-302496626ed64ca98e1fa2fb24af4d92
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07998968B2
来源说明: uspto-grants-2011_08

反应 SMILES

[CH3:1][C:2]1[N:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH3:18])[N:10]=2)[C:6](=[O:19])[C:5]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[NH:37][C:36](=[O:38])[O:35][N:34]=3)=[CH:23][CH:22]=2)=[C:4]([CH2:39][CH2:40][CH3:41])[N:3]=1.[ClH:42].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:42].[CH3:1][C:2]1[N:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH3:18])[N:10]=2)[C:6](=[O:19])[C:5]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[NH:37][C:36](=[O:38])[O:35][N:34]=3)=[CH:23][CH:22]=2)=[C:4]([CH2:39][CH2:40][CH3:41])[N:3]=1