反应详情

温度

80 °C

0.250 g (2.21 mmol) 3,4-dehydro-DL-proline are dissolved in 15 ml of 5% NaHCO3 solution, combined with 0.678 ml (4.42 mmol) 4-chlorophenylisocyanate and stirred for 16 h at 80° C. Then the mixture is cooled, filtered and the residue is washed with water. The filtrate is adjusted to pH 1 with semi-concentrated HCl, extracted 2× with ethyl acetate, dried on sodium sulphate and concentrated i. vac.

1. temperatureThen the mixture is cooled
2. filtrationfiltered
3. washthe residue is washed with water
4. extractionextracted 2× with ethyl acetate
5. customdried on sodium sulphate
6. concentrationconcentrated i