2-Chloro-N-(2-phenylethyl)propanamide → HCID 57437916, compound

HRID 1674489Notes

Reaction equation

HRID 1674489 reaction equation
Cl[CH:2]([CH3:14])[C:3]([NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4].[Cl-].[Cl-].[Cl-].[Al+3]>O.CO>[CH3:14][CH:2]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH2:7][CH2:6][NH:5][C:3]1=[O:4]

Participants

5

Reactant 2

HCID 2027202-Chloro-N-(2-phenylethyl)propanamideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 57437916HCID 57437916, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

8.0 g (37 mmol) 2-chloro-N-(2-phenylethyl)-propanamide and 15 g (112 mmol) aluminium trichloride are carefully mixed at 90° C. and heated to 150° C. for 6 h. The mixture is diluted with water and methanol and extracted with EtOAc. The combined organic phases are dried with Na2SO4, concentrated i. vac. and purified by chromatography.

Workup

  1. extractionextracted with EtOAc
  2. dry with materialThe combined organic phases are dried with Na2SO4
  3. concentrationconcentrated i
  4. customand purified by chromatography

Sources & evidence

ORD record
ord-b8e66e1a7fa8451e91c97e6352ae81b8
Source dataset
uspto-grants-2011_08
Patent number
US08003639B2

Reaction notes

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