Glycol monoethyl ether → HCID 23031993, compound

HRID 1674508Notes

Reaction equation

[CH3:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=2)[N:3]=1.C(OCCO)C.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([CH:29]=[CH:30][CH:31]=1)[NH2:28]>>[CH3:1][C:2]1[N:3]=[C:4]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=2)[CH:5]=[C:6]([NH:28][C:27]2[CH:29]=[CH:30][CH:31]=[C:25]([O:24][CH3:23])[CH:26]=2)[N:7]=1

Participants

Reactant 3

HCID 8076Glycol monoethyl ether

HCID 108243-Methoxyaniline

HCID 23031990HCID 23031990, compound

Product 1

HCID 23031993HCID 23031993, compound

Conditions

Temperature: 130 °C

Procedure

2-methyl-4-chloro-6-(3-hydroxyphenylamino)pyrimidine (0.71 g, 3.0 mmol) was added to a 2-ethoxyethanol (2.0 mL) solution of 3-methoxyaniline (0.37 g, 3.0 mmol) under a nitrogen atmosphere and the reaction mixture stirred for 5 hours at 130° C.

Sources & evidence

ORD record: ord-f2d1ed1ada71430685038dbc0d2d47d5
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08003645B2

Reaction notes

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