反应详情

温度

-78 °C

To a solution of N-(2-chloro-5-formyl-phenyl)-3,4-dimethoxy-benzenesulfonamide (1.77 g, 5 mmol) in THF (20 mL) at −78° C. was added dropwise a solution of methyl lithium in ether (1.6 M, 8.6 mL, 2.75 eq). The mixture was stirred at −78° C. for 30 min and then allowed to warm to RT. The mixture was partitioned between EA and NH4Cl solution, the aqueous phase was once more extracted with EA and the combined organic layers were dried over MgSO4 and concentrated. The residue was dried under hv to give the desired product (1.8 g, 100%) as a yellowish oil.

1. temperatureto warm to RT
2. customThe mixture was partitioned between EA and NH4Cl solution
3. extractionthe aqueous phase was once more extracted with EA
4. dry with materialthe combined organic layers were dried over MgSO4
5. concentrationconcentrated
6. customThe residue was dried under hv