Ethylamine → N-{[6-(Trifluoromethyl)pyridin-2-yl]methyl}ethanamine

HRID 1674647Notes

Reaction equation

HRID 1674647 reaction equation

[F:1][C:2]([F:12])([F:11])[C:3]1[N:8]=[C:7]([CH:9]=O)[CH:6]=[CH:5][CH:4]=1.[CH2:13]([NH2:15])[CH3:14]>C1COCC1>[CH2:13]([NH:15][CH2:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([C:2]([F:12])([F:11])[F:1])[N:8]=1)[CH3:14]

Participants

4

Reactant 2

HCID 6341Ethylamine

HCID 147614746-(Trifluoromethyl)pyridine-2-carbaldehyde

Product 1

HCID 57511315N-{[6-(Trifluoromethyl)pyridin-2-yl]methyl}ethanamine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

prepared by reaction of 6-trifluoromethyl-pyridin-2-carbaldehyde (Ashimori A. Chem. Pharm. Bull. 1990, 38, 9, 2446-2458) with 2M ethylamine in THF.

Sources & evidence

ORD record: ord-be5038c4e0c94b9292b9653fbfdc4aee
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08003654B2

Reaction notes

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