5-Bromo-2-chloro-4-(methylthio)pyrimidine → HCID 59550889, compound

HRID 1674691Notes

Reaction equation

HRID 1674691 reaction equation
[Br:1][C:2]1[C:3]([S:9][CH3:10])=[N:4][C:5](Cl)=[N:6][CH:7]=1.[NH2:11][C:12]1[CH:13]=[C:14]([S:18]([CH3:26])(=[N:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[O:19])[CH:15]=[CH:16][CH:17]=1>C(#N)C>[CH2:24]([O:23][C:21]([N:20]=[S:18]([C:14]1[CH:15]=[CH:16][CH:17]=[C:12]([NH:11][C:5]2[N:4]=[C:3]([S:9][CH3:10])[C:2]([Br:1])=[CH:7][N:6]=2)[CH:13]=1)([CH3:26])=[O:19])=[O:22])[CH3:25]

Participants

4

Reactant 2

HCID 122647965-Bromo-2-chloro-4-(methylthio)pyrimidineHCID 59550856HCID 59550856, compound

Product 1

HCID 59550889HCID 59550889, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Intermediate 13 was prepared in analogy to GP 2 by reaction of 2.15 g of Intermediate 12 (4.5 mmol, 1 eq.) and 1.09 g of Intermediate 5 (4.5 mmol, 1 eq.) to yield (after crystallization from acetonitrile) 1.2 g of Intermediate 13 (60% yield).

Workup

  1. customto yield

Sources & evidence

ORD record
ord-43df76c199b84c2dbbc348c64b5e97f1
Source dataset
uspto-grants-2011_08
Patent number
US08003655B2

Reaction notes

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