4-Ethoxypyrimidine → (RS)-S-(3-{[5-bromo-4-(methoxy)pyrimidin-2-yl]amino}phenyl)-S-methylsulfoximide

HRID 1674693Notes

Reaction equation

HRID 1674693 reaction equation
C(OC([N:6]=[S:7]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][C:17]2[N:22]=[C:21]([O:23][CH3:24])[C:20]([Br:25])=[CH:19][N:18]=2)[CH:11]=1)([CH3:9])=[O:8])=O)C.C(OC1C=CN=CN=1)C>>[Br:25][C:20]1[C:21]([O:23][CH3:24])=[N:22][C:17]([NH:16][C:12]2[CH:11]=[C:10]([S:7]([CH3:9])(=[NH:6])=[O:8])[CH:15]=[CH:14][CH:13]=2)=[N:18][CH:19]=1

Participants

3

Reactant 2

HCID 122449414-EthoxypyrimidineHCID 57659254HCID 57659254, compound

Product 1

HCID 59684680(RS)-S-(3-{[5-bromo-4-(methoxy)pyrimidin-2-yl]amino}phenyl)-S-methylsulfoximideYield 3%

Procedure

Intermediate 14a was prepared in analogy to GP 9 by reaction of Intermediate 14 (500 mg (1.16 mmol) to give, aside a larger quantity of the corresponding 4-ethoxypyrimidine, 14 mg (3%) of the desired product.

Workup

  1. customto give

Sources & evidence

ORD record
ord-b75d72e3104f4ca8996a809aae9fc2ae
Source dataset
uspto-grants-2011_08
Patent number
US08003655B2

Reaction notes

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