反应详情

温度

104 °C

8.24 g (41.2 mmol) (RS)-S-(3-nitrophenyl)-S-methylsulfoximide (Intermediate 4, step 1) in 370 ml toluene were treated with 13.6 mL (138.3 mmol) isopropyl isocyanate. The mixture was stirred under argon at 104° C. for 5 hours and at room temperature for 60 hours. 4.5 mL (46 mmol) isopropyl isocyanate were added and the mixture was stirred under argon at 104° C. for 6 hours and at room temperature for 16 hours. 4.5 ml (46 mmol) isopropyl isocyanate were added and the mixture was stirred under argon at 104° C. for 7 hours and at room temperature for 17 hours. The mixture was cooled with ice for 40 minutes.

1. stirringthe mixture was stirred under argon at 104° C. for 6 hours and at room temperature for 16 hours
2. stirringthe mixture was stirred under argon at 104° C. for 7 hours and at room temperature for 17 hours
3. temperatureThe mixture was cooled with ice for 40 minutes