Benzhydrylpiperazine → 6-(4-Benzhydrylpiperazin-1-yl)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine

HRID 1674772Notes

Reaction equation

HRID 1674772 reaction equation
[CH:1]([N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:20][C:21]1[N:25]2[N:26]=[C:27](Cl)[CH:28]=[CH:29][C:24]2=[N:23][N:22]=1>>[CH:1]([N:14]1[CH2:19][CH2:18][N:17]([C:27]2[CH:28]=[CH:29][C:24]3[N:25]([C:21]([Cl:20])=[N:22][N:23]=3)[N:26]=2)[CH2:16][CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 70048BenzhydrylpiperazineHCID 14823463,6-Dichloro[1,2,4]triazolo[4,3-b]pyridazine

Product 1

HCID 673405786-(4-Benzhydrylpiperazin-1-yl)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine

Procedure

A mixture of 1-benzhydrylpiperazine and 3,6-dichloro-1,2,4-triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 2 to give 6-(4-benzhydrylpiperazin-1-yl)-3-chloro-[1,2,4]triazolo[4,3-b]pyridazine.

Workup

  1. customto react by General Synthetic Method 2

Sources & evidence

ORD record
ord-740ef51c073747b58598cd61e5cf2e50
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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