1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → HCID 67341633, compound

HRID 1674784Notes

Reaction equation

HRID 1674784 reaction equation
[C:1]1([N:7]2[C:11]3([CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[C:10](=[O:17])[NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:19]1[CH:20]=[CH:21][C:22]2[N:23]([C:25]([C:28]([F:31])([F:30])[F:29])=[N:26][N:27]=2)[N:24]=1>>[C:1]1([N:7]2[C:11]3([CH2:12][CH2:13][N:14]([C:19]4[CH:20]=[CH:21][C:22]5[N:23]([C:25]([C:28]([F:29])([F:31])[F:30])=[N:26][N:27]=5)[N:24]=4)[CH2:15][CH2:16]3)[C:10](=[O:17])[NH:9][CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 6136576-Chloro-3-(trifluoromethyl)-(1,2,4)triazolo(4,3-b)pyridazine

Product 1

HCID 67341633HCID 67341633, compound

Procedure

A mixture of 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 3. The crude product was purified by hplc using a Waters XTerra C18 column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 1-phenyl-8-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-1,3,8-triazaspiro[4.5]decan-4-one.

Workup

  1. customto react by General Synthetic Method 3
  2. customThe crude product was purified by hplc
  3. washeluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents

Sources & evidence

ORD record
ord-d4f211fc4c8745888254aee3f4ebe31c
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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