1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → HCID 67341633, compound

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Reaction Steps

A mixture of 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one and 6-chloro-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 3. The crude product was purified by hplc using a Waters XTerra C18 column (5μ silica, 19 mm diameter, 100 mm length) eluted with decreasingly polar mixtures of water (containing 0.1% aqueous ammonia) and acetonitrile as eluents to give 1-phenyl-8-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-1,3,8-triazaspiro[4.5]decan-4-one.

Provenance & Evidence