3-Pyridinecarboxaldehyde → HCID 59149688, compound

HRID 1674977Notes

Reaction equation

HRID 1674977 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=O)[CH:2]=1.[CH3:9][C@@H:10]1[CH2:15][NH:14][C@@H:13]([CH3:16])[CH2:12][N:11]1[C:17]1[CH:18]=[CH:19][C:20]2[N:21]([C:23]([C:26]([F:29])([F:28])[F:27])=[N:24][N:25]=2)[N:22]=1>>[CH3:9][C@@H:10]1[CH2:15][N:14]([CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[C@@H:13]([CH3:16])[CH2:12][N:11]1[C:17]1[CH:18]=[CH:19][C:20]2[N:21]([C:23]([C:26]([F:29])([F:28])[F:27])=[N:24][N:25]=2)[N:22]=1

Participants

3

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 67341170HCID 67341170, compound

Product 1

HCID 59149688HCID 59149688, compoundYield 84%

Procedure

A mixture of pyridine-3-carboxaldehyde and 6-[(2R,5S)-2,5-dimethylpiperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine was allowed to react by General Synthetic Method 5 to give 6-[(2R,5S)-2,5-dimethyl-4-(3-pyridylmethyl)piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine in 84% yield.

Workup

  1. customto react by General Synthetic Method 5

Sources & evidence

ORD record
ord-8d2420a9b64543fda06e16ee724df42f
Source dataset
uspto-grants-2011_08
Patent number
US08003649B2

Reaction notes

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